Membrane domains and macromolecular transport in intestinal epithelial cells
Details
Serval ID
serval:BIB_5B3CABD1A0B6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Membrane domains and macromolecular transport in intestinal epithelial cells
Journal
American Review of Respiratory Disease
ISSN
0003-0805 (Print)
Publication state
Published
Issued date
12/1988
Volume
138
Number
6 Pt 2
Pages
S10-6
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Abstract
Epithelial cell plasma membranes are organized as biochemically and functionally distinct domains and subdomains. We have explored the composition and maintenance of specific membrane regions during endocytosis and transepithelial vesicular transport in specialized cells of the intestinal epithelium. A unique membrane glycoprotein has been identified in apical endocytic subdomains and endosomal tubules of absorptive cells in suckling rat ileum. This endocytic system is involved in sorting and transepithelial transport of peptide growth factors as well as delivery of milk macromolecules to lysosomes. In M cells of follicle-associated epithelium, we have shown that membrane-bound proteins are efficiently transported to a specialized subdomain of basolateral membrane. The apical membranes of these cells bear immunoglobulin binding sites and transport monoclonal IgA antibodies to the basolateral side, where they may interact with cells of the mucosal immune system.
Keywords
Absorption
Animals
Biological Transport
Cell Membrane/immunology/*metabolism
Endocytosis
Epithelium/metabolism
Glycoproteins/metabolism
Intestine, Small/cytology/*metabolism
Rats
Pubmed
Web of science
Create date
25/01/2008 15:05
Last modification date
20/08/2019 14:14