Is it worth treating fever in intensive care unit patients? Preliminary results from a randomized trial of the effect of external cooling.

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State: Public
Version: author
Serval ID
serval:BIB_5B046DB90835
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Is it worth treating fever in intensive care unit patients? Preliminary results from a randomized trial of the effect of external cooling.
Journal
Archives of Internal Medicine
Author(s)
Gozzoli V., Schöttker P., Suter P.M., Ricou B.
ISSN
0003-9926 (Print)
ISSN-L
0003-9926
Publication state
Published
Issued date
2001
Volume
161
Number
1
Pages
121-123
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial Publication Status: ppublish
Abstract
BACKGROUND: Antipyresis is a common clinical practice in intensive care, although it is unknown if fever is harmful, beneficial, or a negligible adverse effect of infection and inflammation.
METHODS: In a randomized study, rectal temperature and discomfort were assessed in 38 surgical intensive care unit patients without neurotrauma or severe hypoxemia and with fever (temperature >/=38.5 degrees C) and systemic inflammatory response syndrome. Eighteen patients received external cooling while 20 received no antipyretic treatment.
RESULTS: Temperature and discomfort decreased similarly in both groups after 24 hours. No significant differences in recurrence of fever, incidence of infection, antibiotic therapy, intensive care unit and hospital length of stay, or mortality were noted between the groups.
CONCLUSIONS: These results suggest that the systematic suppression of fever may not be useful in patients without severe cranial trauma or significant hypoxemia. Letting fever take its natural course does not seem to harm patients with systemic inflammatory response syndrome or influence the discomfort level and may save costs.
Keywords
Analysis of Variance, Body Temperature, Cryotherapy/methods, Female, Fever/therapy, Humans, Intensive Care Units, Length of Stay, Male, Prospective Studies, Rectum/physiology, Recurrence
Pubmed
Web of science
Create date
07/01/2013 15:43
Last modification date
20/08/2019 15:13
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