Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale.

Meier, D.; Skalidis, I.; De Bruyne, B.; Qanadli, S.D.; Rotzinger, D.; Eeckhout, E.; Collet, C.; Muller, O.; Fournier, S.

doi:10.1016/j.ijcha.2020.100496

Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale.

Details

Download: 32181323_BIB_5AF61B593B48.pdf (517.32 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_5AF61B593B48

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale.

Journal

International journal of cardiology. Heart & vasculature

Author(s)

Meier D., Skalidis I., De Bruyne B., Qanadli S.D., Rotzinger D., Eeckhout E., Collet C., Muller O., Fournier S.

ISSN

2352-9067 (Print)

ISSN-L

2352-9067

Publication state

Published

Issued date

04/2020

Peer-reviewed

Oui

Volume

Pages

100496

Language

english

Notes

Publication types: Journal Article
Publication Status: epublish

Abstract

In the era of High-sensitive troponin (hs-Tn), up to 50% of patients with a mild increase of hs-Tn will finally have a normal invasive coronary angiogram. Fractional Flow Reserve (FFR) derived from coronary computed tomographic angiography (FFR-CT) has never been used as a non-invasive tool for the diagnosis of coronary artery disease in patients with high-risk acute coronary syndrome without ST segment elevation (NSTE-ACS).
The study aims to determine the role of coronary CT angiography and FFR-CT in the setting of high-risk NSTE-ACS.
We will conduct a prospective trial, enrolling 250 patients admitted with high-risk NSTE-ACS who will rapidly undergo a coronary CT angiography and then a coronary angiography with FFR measurements. Results of coronary CT, FFR-CT and coronary angiography (± FFR) will be compared.
In conclusion, non-invasive identification of patients with high-risk NSTE-ACS who could avoid coronary angiography would reduce procedure related risks and medical costs.

Keywords

ACS, Acute coronary syndrome, AE, Adverse Event, Acute coronary syndrome, CMRI, Cardiac Magnetic resonance imaging, CT, Computed tomography, Coronary computed tomography, ECG, Electrocardiogram, ED, Emergency department, FFR, Fractional Flow Reserve, FFR-CT, FFR-CT, FFR derived from coronary CT, Fractional Flow Reserve, Hs-Tn, High-sensitive troponins, MACE, Major adverse cardiac events, MI, Myocardial infraction, NSTE-ACS, Acute coronary syndromes without ST-segment elevation, NSTEMI, Non-ST-elevation myocardial infarction, PCI, Percutaneous Coronary Intervention, STEMI, ST-elevation myocardial infarction, URL, Upper Range Limit

URN

urn:nbn:ch:serval-BIB_5AF61B593B483

OAI-PMH

oai:serval.unil.ch:BIB_5AF61B593B48

DOI

10.1016/j.ijcha.2020.100496

Pubmed

32181323

Open Access

Yes

Create date

02/04/2020 15:57