Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale.

Details

Serval ID
serval:BIB_5AF61B593B48
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ability of FFR-CT to detect the absence of hemodynamically significant lesions in patients with high-risk NSTE-ACS admitted in the emergency department with chest pain, study design and rationale.
Journal
International journal of cardiology. Heart & vasculature
Author(s)
Meier D., Skalidis I., De Bruyne B., Qanadli S.D., Rotzinger D., Eeckhout E., Collet C., Muller O., Fournier S.
ISSN
2352-9067 (Print)
ISSN-L
2352-9067
Publication state
Published
Issued date
04/2020
Peer-reviewed
Oui
Volume
27
Pages
100496
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In the era of High-sensitive troponin (hs-Tn), up to 50% of patients with a mild increase of hs-Tn will finally have a normal invasive coronary angiogram. Fractional Flow Reserve (FFR) derived from coronary computed tomographic angiography (FFR-CT) has never been used as a non-invasive tool for the diagnosis of coronary artery disease in patients with high-risk acute coronary syndrome without ST segment elevation (NSTE-ACS).
The study aims to determine the role of coronary CT angiography and FFR-CT in the setting of high-risk NSTE-ACS.
We will conduct a prospective trial, enrolling 250 patients admitted with high-risk NSTE-ACS who will rapidly undergo a coronary CT angiography and then a coronary angiography with FFR measurements. Results of coronary CT, FFR-CT and coronary angiography (± FFR) will be compared.
In conclusion, non-invasive identification of patients with high-risk NSTE-ACS who could avoid coronary angiography would reduce procedure related risks and medical costs.
Keywords
ACS, Acute coronary syndrome, AE, Adverse Event, Acute coronary syndrome, CMRI, Cardiac Magnetic resonance imaging, CT, Computed tomography, Coronary computed tomography, ECG, Electrocardiogram, ED, Emergency department, FFR, Fractional Flow Reserve, FFR-CT, FFR-CT, FFR derived from coronary CT, Fractional Flow Reserve, Hs-Tn, High-sensitive troponins, MACE, Major adverse cardiac events, MI, Myocardial infraction, NSTE-ACS, Acute coronary syndromes without ST-segment elevation, NSTEMI, Non-ST-elevation myocardial infarction, PCI, Percutaneous Coronary Intervention, STEMI, ST-elevation myocardial infarction, URL, Upper Range Limit
Pubmed
Open Access
Yes
Create date
02/04/2020 16:57
Last modification date
25/04/2020 6:26
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