Propofol in der Neuroanasthesie. [Propofol for neuroanesthesia]

Details

Serval ID
serval:BIB_5AC49F96E3D2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Propofol in der Neuroanasthesie. [Propofol for neuroanesthesia]
Journal
Anaesthesist
Author(s)
Ravussin  P., Strebel  S.
ISSN
0003-2417
Publication state
Published
Issued date
06/1995
Peer-reviewed
Oui
Volume
44
Number
6
Pages
405-9
Notes
English Abstract
Journal Article
Review --- Old month value: Jun
Abstract
The quality, result, and prognosis of neurosurgery relies heavily on the anaesthetic technique. Many different classes of drugs have been used during neurosurgical anaesthesia. This article reviews the use of intravenous (IV) propofol as an alternative to volatile anaesthetic techniques. Anaesthesia requirements for neurosurgical procedures are elaborated upon in the first part of the article. The priority of neuroanaesthesia is to preserve neuronal function by avoiding complications such as hypoxia, hypercarbia, and cardiovascular instability. Thereafter, the chosen anaesthetic technique should minimally interfere with cerebral autoregulation and CO2 responsiveness, while brain relaxation is encouraged by decreasing the cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF). In addition, the anaesthetic technique should be associated with rapid and predictable recovery in the operating theatre in order to allow early evaluation of the surgery. The second part of the article describes IV techniques for neurosurgery as an alternative to volatile anaesthetics, all of which increase CBF, cerebral blood volume, and intracranial pressure (ICP) in a dose-related manner and diminish cerebral autoregulation and interfere with cerebrovascular CO2 reactivity. Nitrous oxide has a stimulant effect on cerebral metabolism and is associated with an increase in CBF. On the other hand, all IV agents except ketamine are associated with decreases in CMRO2 and are cerebral vasoconstrictors. For this reason, it is rational to use them for the induction and maintenance of anaesthesia for neurosurgery as part of a total IV anaesthetic technique. The third part of the article focuses on propofol as the newest representative of IV anaesthetics.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
*Anesthesia, Intravenous Humans *Neurosurgery *Propofol/administration & dosage
Pubmed
Web of science
Create date
17/01/2008 16:19
Last modification date
20/08/2019 14:13
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