Acetazolamide Reduces Retinal Inner Nuclear Layer Thickness in Microcystic Macular Edema Secondary to Optic Neuropathy.

Details

Serval ID
serval:BIB_5A90EA2BD7E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acetazolamide Reduces Retinal Inner Nuclear Layer Thickness in Microcystic Macular Edema Secondary to Optic Neuropathy.
Journal
European neurology
Author(s)
Borruat F.X., Dysli M., Voide N., Abegg M.
ISSN
1421-9913 (Electronic)
ISSN-L
0014-3022
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
79
Number
3-4
Pages
150-153
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Optic neuropathy (ON) is commonly complicated by microcystic macular edema (MME), that is, small vertical cystoid spaces in the inner nuclear layer (INL) of the macula. We performed a retrospective consecutive case series of 14 eyes from 11 patients with ON and MME that were treated with oral acetazolamide, acting on cellular water transport. Contralateral eyes without MME were used as controls. Segmentation of images obtained with OCT was used to determine changes of individual retinal layer thickness during treatment. Retinal INL thickness consistently decreased in all eyes after 2-3 weeks of treatment. Recurrence of MME was observed after treatment cessation. No significant change of retinal thickness was found in contralateral unaffected eyes. Visual function did not change with treatment. Acetazolamide significantly improved the MME in eyes with ON. However, visual function did not. Acetazolamide is a treatment option for MME associated with ON but without an impact on the visual function.
Keywords
Acetazolamide/therapeutic use, Adult, Aged, Diuretics/therapeutic use, Female, Humans, Macular Edema/drug therapy, Macular Edema/etiology, Male, Middle Aged, Optic Nerve Diseases/complications, Retina/drug effects, Retrospective Studies, Tomography, Optical Coherence, Acetazolamide, Microcystic macular edema, Optic neuropathy, Optical coherence tomography segmentation, Retinal inner nuclear layer
Pubmed
Web of science
Create date
08/03/2018 21:22
Last modification date
20/08/2019 15:13
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