Low placental weight and altered metabolic scaling after severe acute respiratory syndrome coronavirus type 2 infection during pregnancy: a prospective multicentric study.

Details

Serval ID
serval:BIB_5A7E6008DBDB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Low placental weight and altered metabolic scaling after severe acute respiratory syndrome coronavirus type 2 infection during pregnancy: a prospective multicentric study.
Journal
Clinical microbiology and infection
Author(s)
Radan A.P., Baud D., Favre G., Papadia A., Surbek D., Baumann M., Raio L.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Publication state
Published
Issued date
05/2022
Peer-reviewed
Oui
Volume
28
Number
5
Pages
718-722
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
A higher risk of adverse pregnancy outcomes is associated with SARS-CoV-2 infection; this could be partially explained by an altered placental function. Because histopathology is often unspecific, we aimed to assess placental weight, birthweight/placental weight (b/p) ratio, and the metabolic scaling exponent ß, an indicator of normal fetal-placental growth, to analyze placental function.
We included 153 singleton pregnancies with SARS-CoV-2-positive PCR result who delivered at three referring hospitals in Switzerland. Placental weight and b/p ratio were compared to published reference charts. Logistic regression analysis investigated the role of time of infection and other confounding factors on placental weight. The scaling exponent β was compared to the reference value of 0.75.
Placental weight was inferior or equal to the tenth centile in 42.5% (65 of 153) and to the third centile in 19% (29 of 153) of the cases. The risk of low placental weight was not influenced by the trimester in which infection occurred. The b/p ratio was >50th centile in 80.4% (123 of 153) of the cases. The incidence of foetal growth restriction, preeclampsia, and gestational diabetes was 11.8% (18 of 153), 3.3% (5 of 153), and 19.6% (30 of 153). Linear regression modelling revealed a pathologic metabolic scaling exponent β of 0.871 ± 0.064 (R <sup>2</sup> = 0.56).
SARS-CoV-2 infection during pregnancy was associated with a higher incidence of low placental weight, an increased b/p ratio, and an abnormal scaling exponent β in our cohort. This could be particularly relevant for the still controversial issue of an increased stillbirth rate in SARS-CoV-2 infection during pregnancy. In this regard, intensified foetal surveillance should be mandatory in these pregnancies.
Keywords
COVID-19/epidemiology, Diabetes Mellitus, Type 2, Female, Humans, Placenta, Pregnancy, Pregnancy Complications, Infectious/epidemiology, Pregnancy Complications, Infectious/pathology, Pregnancy Outcome, Prospective Studies, SARS-CoV-2, Birth weight/placental weight ratio, COVID-19, Metabolic scaling exponent β, Placental weight
Pubmed
Open Access
Yes
Create date
19/02/2022 12:30
Last modification date
28/05/2022 6:34
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