Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.

Details

Serval ID
serval:BIB_5A7B1E7B7109
Type
Article: article from journal or magazin.
Collection
Publications
Title
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
Journal
The Journal of experimental medicine
Author(s)
Lichterfeld M., Kaufmann D.E., Yu X.G., Mui S.K., Addo M.M., Johnston M.N., Cohen D., Robbins G.K., Pae E., Alter G., Wurcel A., Stone D., Rosenberg E.S., Walker B.D., Altfeld M.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
20/09/2004
Peer-reviewed
Oui
Volume
200
Number
6
Pages
701-712
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Virus-specific CD8(+) T cells are associated with declining viremia in acute human immunodeficiency virus (HIV)1 infection, but do not correlate with control of viremia in chronic infection, suggesting a progressive functional defect not measured by interferon gamma assays presently used. Here, we demonstrate that HIV-1-specific CD8(+) T cells proliferate rapidly upon encounter with cognate antigen in acute infection, but lose this capacity with ongoing viral replication. This functional defect can be induced in vitro by depletion of CD4(+) T cells or addition of interleukin 2-neutralizing antibodies, and can be corrected in chronic infection in vitro by addition of autologous CD4(+) T cells isolated during acute infection and in vivo by vaccine-mediated induction of HIV-1-specific CD4(+) T helper cell responses. These data demonstrate a loss of HIV-1-specific CD8(+) T cell function that not only correlates with progressive infection, but also can be restored in chronic infection by augmentation of HIV-1-specific T helper cell function. This identification of a reversible defect in cell-mediated immunity in chronic HIV-1 infection has important implications for immunotherapeutic interventions.
Keywords
AIDS Vaccines/immunology, Acquired Immunodeficiency Syndrome/immunology, Acute Disease, Adult, Amino Acid Sequence, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Cells, Cultured, Female, HIV-1/immunology, Humans, Interferon-gamma/biosynthesis, Interleukin-2/physiology, Lymphocyte Activation, Male, Middle Aged, Molecular Sequence Data
Pubmed
Web of science
Open Access
Yes
Create date
09/05/2023 13:00
Last modification date
29/11/2024 17:19
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