Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.

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Serval ID
serval:BIB_5A75094A411B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.
Journal
The Journal of experimental medicine
Author(s)
Cobas M., Wilson A., Ernst B., Mancini S.J., MacDonald H.R., Kemler R., Radtke F.
ISSN
0022-1007
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
199
Number
2
Pages
221-229
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is beta-catenin independent. In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
Keywords
Animals, B-Lymphocytes/cytology, B-Lymphocytes/immunology, Cell Differentiation, Cell Division, Chimera, Cytoskeletal Proteins/deficiency, Cytoskeletal Proteins/genetics, Female, Hematopoiesis/genetics, Hematopoiesis/physiology, Integrases/genetics, Lymphopoiesis/genetics, Lymphopoiesis/physiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Proto-Oncogene Proteins/genetics, Proto-Oncogene Proteins/physiology, Signal Transduction, T-Lymphocytes/cytology, T-Lymphocytes/immunology, Trans-Activators/deficiency, Trans-Activators/genetics, Wnt Proteins, beta Catenin
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:39
Last modification date
20/08/2019 15:13
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