Genomic approaches to the study of HIV‐1 acquisition.

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Serval ID
serval:BIB_5A4E11FF573B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genomic approaches to the study of HIV‐1 acquisition.
Journal
Journal of Infectious Diseases
Author(s)
Telenti Amalio, McLaren Paul
ISSN
1537-6613[electronic], 0022-1899[linking]
Publication state
Published
Issued date
2010
Volume
202
Number
Suppl 3
Pages
S382-S386
Language
english
Abstract
Host genome studies are increasingly available for the study of infectious disease susceptibility. Current technologies include large-scale genotyping, genome-wide screens such as transcriptome and silencing (silencing RNA) studies, and increasingly, the possibility to sequence complete genomes. These approaches are of interest for the study of individuals who remain uninfected despite documented exposure to human immunodeficiency virus type 1. The main limitation remains the ascertainment of exposure and establishing large cohorts of informative individuals. The pattern of enrichment for CCR5 Δ32 homozygosis should serve as the standard for assessing the extent to which a given cohort (of white subjects) includes a large proportion of exposed uninfected individuals.
Keywords
genomewide association, wide association, hepatitis-c, infection, il28b, aids, rna
Pubmed
Web of science
Open Access
Yes
Create date
27/10/2010 13:54
Last modification date
25/09/2019 7:09
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