Mobilizable genomic islands, different strategies for the dissemination of multidrug resistance and other adaptive traits.

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Version: Final published version
Serval ID
serval:BIB_5A28AD4C9121
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Title
Mobilizable genomic islands, different strategies for the dissemination of multidrug resistance and other adaptive traits.
Journal
Mobile Genetic Elements
Author(s)
Carraro N., Rivard N., Burrus V., Ceccarelli D.
ISSN
2159-2543 (Print)
ISSN-L
2159-2543
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
7
Number
2
Pages
1-6
Language
english
Abstract
Mobile genetic elements are near ubiquitous DNA segments that revealed a surprising variety of strategies for their propagation among prokaryotes and between eukaryotes. In bacteria, conjugative elements were shown to be key drivers of evolution and adaptation by efficiently disseminating genes involved in pathogenicity, symbiosis, metabolic pathways, and antibiotic resistance. Conjugative plasmids of the incompatibility groups A and C (A/C) are important vehicles for the dissemination of antibiotic resistance and the consequent global emergence and spread of multi-resistant pathogenic bacteria. Beyond their own mobility, A/C plasmids were also shown to drive the mobility of unrelated non-autonomous mobilizable genomic islands, which may also confer further advantageous traits. In this commentary, we summarize the current knowledge on different classes of A/C-dependent mobilizable genomic islands and we discuss other DNA hitchhikers and their implication in bacterial evolution. Furthermore, we glimpse at the complex genetic network linking autonomous and non-autonomous mobile genetic elements, and at the associated flow of genetic information between bacteria.

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29/04/2017 16:44
Last modification date
20/08/2019 15:13
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