Macrophage migration inhibitory factor: gene polymorphisms and susceptibility to inflammatory diseases

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Serval ID
serval:BIB_5A232E2AFB66
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Macrophage migration inhibitory factor: gene polymorphisms and susceptibility to inflammatory diseases
Journal
Clinical Infectious Diseases
Author(s)
Renner  P., Roger  T., Calandra  T.
ISSN
1537-6591 (Electronic)
Publication state
Published
Issued date
11/2005
Volume
41 Suppl 7
Pages
S513-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Nov 15
Abstract
The cytokine macrophage migration inhibitory factor (MIF) is a constitutive element of the host antimicrobial defenses and stress response that promotes proinflammatory function of the innate and acquired immune systems. MIF plays an important role in the pathogenesis of acute and chronic inflammatory or autoimmune disorders, such as sepsis, acute respiratory distress syndrome, asthma, rheumatoid arthritis, and inflammatory bowel diseases. Polymorphisms of the human MIF gene (that is, guanine-to-cytosine transition at position -173 or CATT-tetranucleotide repeat at position -794) have been associated with increased susceptibility to or severity of juvenile idiopathic and adult rheumatoid arthritis, ulcerative colitis, atopy, or sarcoidosis. Whether these MIF polymorphisms affect the susceptibility to and outcome of sepsis has not yet been examined. Analyses of MIF genotypes in patients with sepsis may help to classify patients into risk categories and to identify those patients who may benefit from anti-MIF therapeutic strategies.
Keywords
Autoimmune Diseases/*genetics Gene Frequency *Genetic Predisposition to Disease Genotype Humans Immunity, Natural/genetics Inflammatory Bowel Diseases/*genetics Macrophage Migration-Inhibitory Factors/antagonists & inhibitors/*genetics/metabolism Polymorphism, Genetic Sepsis/*genetics/therapy
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:35
Last modification date
25/09/2019 7:09
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