Human chromosome 21 is necessary and sufficient to confer human IFN gamma responsiveness to somatic cell hybrids expressing the cloned human IFN gamma receptor gene.
Details
Serval ID
serval:BIB_5A07DA97085D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human chromosome 21 is necessary and sufficient to confer human IFN gamma responsiveness to somatic cell hybrids expressing the cloned human IFN gamma receptor gene.
Journal
Cytokine
ISSN
1043-4666 (Print)
ISSN-L
1043-4666
Publication state
Published
Issued date
1990
Volume
2
Number
3
Pages
157-161
Language
english
Abstract
The human interferon (IFN) gamma receptor cDNA has been stably expressed in human/mouse somatic cell hybrids, which differ in their content of human chromosome 21. Despite high affinity IFN gamma binding-capacity of all receptor transfectants, biological responsiveness to IFN gamma, as determined by enhancement of mouse-MHC class I gene expression, required the presence of chromosome 21. These data suggest complementation of at least two functionally distinct components in order to create a biologically active IFN gamma receptor.
Keywords
Animals, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 6, Cloning, Molecular, Genetic Complementation Test, H-2 Antigens/physiology, Humans, Hybrid Cells, Interferon-gamma/physiology, Mice, Receptors, Immunologic/physiology, Receptors, Interferon, Transfection
Pubmed
Create date
28/01/2008 12:36
Last modification date
20/08/2019 15:13
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