Value of MRI - T2 Mapping to Differentiate Clinically Significant Prostate Cancer.

Details

Serval ID
serval:BIB_59A51072F184
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Value of MRI - T2 Mapping to Differentiate Clinically Significant Prostate Cancer.
Journal
Journal of imaging informatics in medicine
Author(s)
Bucher A.M., Egger J., Dietz J., Strecker R., Hilbert T., Frodl E., Wenzel M., Penzkofer T., Hamm B., Chun F.K., Vogl T., Kleesiek J., Beeres M.
ISSN
2948-2933 (Electronic)
ISSN-L
2948-2925
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Standardized reporting of multiparametric prostate MRI (mpMRI) is widespread and follows international standards (Pi-RADS). However, quantitative measurements from mpMRI are not widely comparable. Although T2 mapping sequences can provide repeatable quantitative image measurements and extract reliable imaging biomarkers from mpMRI, they are often time-consuming. We therefore investigated the value of quantitative measurements on a highly accelerated T2 mapping sequence, in order to establish a threshold to differentiate benign from malignant lesions. For this purpose, we evaluated a novel, highly accelerated T2 mapping research sequence that enables high-resolution image acquisition with short acquisition times in everyday clinical practice. In this retrospective single-center study, we included 54 patients with clinically indicated MRI of the prostate and biopsy-confirmed carcinoma (n = 37) or exclusion of carcinoma (n = 17). All patients had received a standard of care biopsy of the prostate, results of which were used to confirm or exclude presence of malignant lesions. We used the linear mixed-effects model-fit by REML to determine the difference between mean values of cancerous tissue and healthy tissue. We found good differentiation between malignant lesions and normal appearing tissue in the peripheral zone based on the mean T2 value. Specifically, the mean T2 value for tissue without malignant lesions was (151.7 ms [95% CI: 146.9-156.5 ms] compared to 80.9 ms for malignant lesions [95% CI: 67.9-79.1 ms]; p < 0.001). Based on this assessment, a limit of 109.2 ms is suggested. Aditionally, a significant correlation was observed between T2 values of the peripheral zone and PI-RADS scores (p = 0.0194). However, no correlation was found between the Gleason Score and the T2 relaxation time. Using REML, we found a difference of -82.7 ms in mean values between cancerous tissue and healthy tissue. We established a cut-off-value of 109.2 ms to accurately differentiate between malignant and non-malignant prostate regions. The addition of T2 mapping sequences to routine imaging could benefit automated lesion detection and facilitate contrast-free multiparametric MRI of the prostate.
Keywords
Multiparametric prostate MRI, Prostate cancer, Quantitative imaging, T2 mapping
Pubmed
Open Access
Yes
Create date
28/06/2024 14:14
Last modification date
29/06/2024 9:30
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