Co-incidence of Damage and Microbial Patterns Controls Localized Immune Responses in Roots.

Details

Serval ID
serval:BIB_5936E87123F2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Co-incidence of Damage and Microbial Patterns Controls Localized Immune Responses in Roots.
Journal
Cell
Author(s)
Zhou F., Emonet A., Dénervaud Tendon V., Marhavy P., Wu D., Lahaye T., Geldner N.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Publication state
Published
Issued date
06/02/2020
Peer-reviewed
Oui
Volume
180
Number
3
Pages
440-453.e18
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Recognition of microbe-associated molecular patterns (MAMPs) is crucial for the plant's immune response. How this sophisticated perception system can be usefully deployed in roots, continuously exposed to microbes, remains a mystery. By analyzing MAMP receptor expression and response at cellular resolution in Arabidopsis, we observed that differentiated outer cell layers show low expression of pattern-recognition receptors (PRRs) and lack MAMP responsiveness. Yet, these cells can be gated to become responsive by neighbor cell damage. Laser ablation of small cell clusters strongly upregulates PRR expression in their vicinity, and elevated receptor expression is sufficient to induce responsiveness in non-responsive cells. Finally, localized damage also leads to immune responses to otherwise non-immunogenic, beneficial bacteria. Damage-gating is overridden by receptor overexpression, which antagonizes colonization. Our findings that cellular damage can "switch on" local immune responses helps to conceptualize how MAMP perception can be used despite the presence of microbial patterns in the soil.
Keywords
Arabidopsis, damage-gating, localized response, microbe patterns, pattern-recognition receptors, root immunity
Pubmed
Open Access
Yes
Create date
17/02/2020 16:41
Last modification date
22/02/2020 7:26
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