Hypertension and microvascular remodelling

Details

Ressource 1Download: serval:BIB_5900898F7CFE.P001 (989.33 [Ko])
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Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_5900898F7CFE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Hypertension and microvascular remodelling
Journal
Cardiovascular Research
Author(s)
Feihl F., Liaudet L., Levy B. I., Waeber B.
ISSN
0008-6363
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
78
Number
2
Pages
274-285
Language
english
Abstract
In the present review, microvascular remodelling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Folkow's contribution made half a century ago. We then move to some basic concepts on the biomechanics of blood vessels, and explicit the definitions proposed by Mulvany for specific forms of remodelling, especially inward eutrophic and inward hypertrophic. The available evidence for the existence of remodelled resistance vessels in hypertension comes next, with relatively more weight given to human, in comparison with animal data. Mechanisms are discussed. The impact of antihypertensive drug treatment on remodelling is described, again with emphasis on human data. Some details are given on the three studies to date which point to remodelling of subcutaneous resistance arteries as an independent predictor of cardiovascular risk in hypertensive patients. We terminate by considering the potential role of remodelling in the pathogenesis of end-organ damage and in the perpetuation of hypertension.
Keywords
Adaptation,Physiological, Animals, Antihypertensive Agents, blood, Blood Pressure, drug effects, drug therapy, history, History,19th Century, History,20th Century, Humans, Hyperplasia, Hypertension, Mechanotransduction,Cellular, Microcirculation, Models,Cardiovascular, pathology, Patients, physiopathology, Risk, Role, Stress,Mechanical, Switzerland, Terminology as Topic, therapeutic use, Vascular Resistance
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 23:14
Last modification date
25/09/2019 7:09
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