Trends in Antibiotic Consumption and Resistance in France Over 20 Years: Large and Continuous Efforts but Contrasting Results.

Details

Serval ID
serval:BIB_58E741C47E7E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Trends in Antibiotic Consumption and Resistance in France Over 20 Years: Large and Continuous Efforts but Contrasting Results.
Journal
Open forum infectious diseases
Author(s)
Carlet J., Jarlier V., Acar J., Debaere O., Dehaumont P., Grandbastien B., Le Coz P., Lina G., Pean Y., Rambaud C., Roblot F., Salomon J., Schlemmer B., Tattevin P., Vallet B.
ISSN
2328-8957 (Print)
ISSN-L
2328-8957
Publication state
Published
Issued date
11/2020
Peer-reviewed
Oui
Volume
7
Number
11
Pages
ofaa452
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Antimicrobial resistance (AMR) is a serious threat to humanity. This paper describes the French efforts made since 2001 and presents data on antimicrobial consumption (AC) and AMR.
We gathered all data on AC and AMR recorded since 2001 from different national agencies, transferred on a regular basis to standardized European data on AC and resistance in both humans and animals.
After a large information campaign implemented in France from 2001 to 2005 in humans, AC in the community decreased significantly (18% to 34% according to the calculation method used). It remained at the same level from 2005 to 2010 and increased again from 2010 to 2018 (8%). Contrasting results were observed for AMR. The resistance of Staphylococcus aureus decreased significantly. For gram-negative bacilli, the results were variable according to the microorganism. The resistance of Enterobacteriaceae to third-generation cephalosporins increased, remaining moderate for Escherichia coli (12% in 2017) but reaching 35% in the same year for Klebsiella pneumoniae. Resistance to carbapenems in those 2 microorganisms remained below 1%. Both global AC and resistance to most antibiotics decreased significantly in animals.
Antibiotic consumption decreased significantly in France after a large public campaign from 2001 to 2005, but this positive effect was temporary. The effect on AMR varied according to the specific microorganism: The effect was very impressive for gram-positive cocci, variable for gram-negative bacilli, and moderate for E. coli, but that for K. pneumoniae was of concern. The consumption of and resistance to antibiotics decreased significantly in animals.
Keywords
antibiotic consumption, antibiotic resistance, antibiotics, bacterial transmission, gram-negative bacilli, gram-positive cocci
Pubmed
Web of science
Open Access
Yes
Create date
23/11/2020 14:24
Last modification date
16/04/2024 7:12
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