A missing sugar prevents glucose entry: a new twist on insulin secretion.
Details
Serval ID
serval:BIB_58DB7D37AA11
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A missing sugar prevents glucose entry: a new twist on insulin secretion.
Journal
Cell Metabolism
ISSN
1550-4131[print]
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
3
Number
1
Pages
3-5
Language
english
Abstract
The signaling pathway that regulates glucose-stimulated insulin secretion depends on glucose metabolism, which is itself controlled by glucokinase. In a recent issue of Cell, show that altering N-glycosylation of the GLUT2 glucose transporter prevents its anchoring and retention at the cell surface; this impairs glucose uptake and insulin secretion.
Keywords
Animals, Galectins/metabolism, Glucose/antagonists & inhibitors, Glucose/metabolism, Glucose Transporter Type 2/antagonists & inhibitors, Glucose Transporter Type 2/genetics, Glycosylation, Humans, Insulin/secretion, Mice, N-Acetylglucosaminyltransferases/genetics, N-Acetylglucosaminyltransferases/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:41
Last modification date
20/08/2019 14:12
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