Attention Deficit/Hyperactivity Disorder (ADHD) has prevalence between 3 and 7% in childhood and adolescence. As high as 60% of childhood cases continue to have clinically significant symptoms of ADHD as adults. Psychiatric comorbidities are often found in ADHD subjects including, in childhood, emotional, behavior and learning disorders. Psychiatric comorbidities in adolescents and adults suffering from ADHD include mood and substance use disorders. Although may one fear giving psychostimulants to ADHD patients with comorbidities, recent studies have shown the benefits of such treatment not only in the clinical but also in the educational and socioprofessional point of views. Psychotherapeutic approaches should ideally accompany pharmacological treatments.