Should we include SPECT lung perfusion in radiotherapy treatment plans of thoracic targets? Evidences from the literature.

Details

Serval ID
serval:BIB_58638AE058BE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Should we include SPECT lung perfusion in radiotherapy treatment plans of thoracic targets? Evidences from the literature.
Journal
Critical reviews in oncology/hematology
Author(s)
De Bari B., Deantonio L., Bourhis J., Prior J.O., Ozsahin M.
ISSN
1879-0461 (Electronic)
ISSN-L
1040-8428
Publication state
Published
Issued date
06/2016
Peer-reviewed
Oui
Volume
102
Pages
111-117
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
To report the available data about the potential impact of integrating lung perfusion SPECT/CT in treatment plans optimization for the irradiation of thoracic targets.
We searched in the PubMed and Scopus databases, English-written articles published from 2000 to June 2015 dealing with the integration of perfusion SPECT/CT in radiotherapy.
We found and analyzed 16 research articles (10 dosimetric, 6 clinical) for a total of 578 patients. Available data suggest dosimetric and clinical improvements when perfusion SPEC/CT is integrated in the radiotherapy treatment planing of selected patients with thoracic targets. In particular, patients presenting emphysema and/or large areas of deficit of perfusion show the most important improvements. Moreover, some studies show different risk of radiation pneumonitis (RP) depending on the localization of the tumor in the lungs: patients with low-located tumors, present an increased risk of RP, and functional data could be a benefit in treatment plan optimization. Unfortunately, none of the available studies finally reports any dosimetric constraint, which could be used in the clinical practice, even if most of them used the cut-off of the 30% of the maximal perfusion value to define the well-functioning lung.
Published data support the integration of lung perfusion scintigraphy in some selected categories of patients. Prospective studies should be designed to define the best candidates, and to assess the clinical advantage of this kind of optimization.

Keywords
Humans, Lung/diagnostic imaging, Lung Neoplasms/diagnostic imaging, Lung Neoplasms/drug therapy, Lung Neoplasms/radiotherapy, Radiation Pneumonitis, Tomography, Emission-Computed, Single-Photon
Pubmed
Create date
17/05/2016 17:59
Last modification date
20/08/2019 14:12
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