Biochemical Differences Between Vitreous Humor and Cerebral Spinal Fluid in a Death From Diabetic Ketoacidosis.

Details

Serval ID
serval:BIB_583D7709CAC7
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Biochemical Differences Between Vitreous Humor and Cerebral Spinal Fluid in a Death From Diabetic Ketoacidosis.
Journal
The American journal of forensic medicine and pathology
Author(s)
Garland J., Philcox W., Kesha K., McCarthy S., Lam L., Palmiere C., OʼRegan T., Stables S., Tse R.
ISSN
1533-404X (Electronic)
ISSN-L
0195-7910
Publication state
Published
Issued date
20/11/2018
Peer-reviewed
Oui
Volume
40
Number
2
Pages
188-191
Language
english
Notes
Publication types: Journal Article
Abstract
Biochemical analysis of cerebrospinal fluid (CSF) and vitreous humor (VH) forms an important diagnostic ancillary test at autopsy. Cerebrospinal fluid can be sampled from the ventricular system (VA) and from lumbar puncture (LP), whereas VH can be sampled from the orbits. Biochemical electrolytes seem to vary between VH and CSF collected from different sites, but whether there is any difference in glucose and β-hydroxybutyrate is unclear. We present a case report of a 21-year-old man who died of diabetic ketoacidosis confirmed at autopsy. Ventricular system, LP, and VH were biochemically analyzed and showed that glucose was highest in VH (41 mmol/L) and was 6 and 8 mmol/L higher than CSF in the LP and VA, respectively. β-Hydroxybutyrate was also highest in VH (20 mmol/L) and was 5 and 6 mmol/L higher than LP and VA, respectively. Our findings suggest that postmortem CSF glucose and β-hydroxybutyrate may not truly reflect that of VH and vary between CSF sampling sites.
Pubmed
Web of science
Create date
04/01/2019 14:55
Last modification date
20/12/2019 6:22
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