Baroreflex sensitivity is blunted in hypoxia independently of changes in inspired carbon dioxide pressure in prematurely born male adults.

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Version: author
License: CC BY 4.0
Serval ID
serval:BIB_57E5C5E20430
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Baroreflex sensitivity is blunted in hypoxia independently of changes in inspired carbon dioxide pressure in prematurely born male adults.
Journal
Physiological reports
Author(s)
Manferdelli G., Narang B.J., Bourdillon N., Debevec T., Millet G.P.
ISSN
2051-817X (Electronic)
ISSN-L
2051-817X
Publication state
Published
Issued date
01/2024
Peer-reviewed
Oui
Volume
12
Number
1
Pages
e15857
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Premature birth may result in specific cardiovascular responses to hypoxia and hypercapnia, that might hamper high-altitude acclimatization. This study investigated the consequences of premature birth on baroreflex sensitivity (BRS) under hypoxic, hypobaric and hypercapnic conditions. Seventeen preterm born males (gestational age, 29 ± 1 weeks), and 17 age-matched term born adults (40 ± 0 weeks) underwent consecutive 6-min stages breathing different oxygen and carbon dioxide concentrations at both sea-level and high-altitude (3375 m). Continuous blood pressure and ventilatory parameters were recorded in normobaric normoxia (NNx), normobaric normoxic hypercapnia (NNx + CO <sub>2</sub> ), hypobaric hypoxia (HHx), hypobaric normoxia (HNx), hypobaric normoxia hypercapnia (HNx + CO <sub>2</sub> ), and hypobaric hypoxia with end-tidal CO <sub>2</sub> clamped at NNx value (HHx + clamp). BRS was assessed using the sequence method. Across all conditions, BRS was lower in term born compared to preterm (13.0 ± 7.5 vs. 21.2 ± 8.8 ms⋅mmHg <sup>-1</sup> , main group effect: p < 0.01) participants. BRS was lower in HHx compared to NNx in term born (10.5 ± 4.9 vs. 16.0 ± 6.0 ms⋅mmHg <sup>-1</sup> , p = 0.05), but not in preterm (27.3 ± 15.7 vs. 17.6 ± 8.3 ms⋅mmHg <sup>-1</sup> , p = 0.43) participants, leading to a lower BRS in HHx in term born compared to preterm (p < 0.01). In conclusion, this study reports a blunted response of BRS during acute high-altitude exposure without any influence of changes in inspired CO <sub>2</sub> in healthy prematurely born adults.
Keywords
Adult, Female, Infant, Newborn, Male, Humans, Infant, Carbon Dioxide, Hypercapnia, Baroreflex, Premature Birth, Hypoxia, Oxygen, Altitude, altitude, baroreflex, hypercapnia, hypobaria, preterm
Pubmed
Open Access
Yes
Create date
10/01/2024 14:25
Last modification date
19/01/2024 8:12
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