Classification of neuroendocrine neoplasms: lights and shadows.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_57C21FC6421F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Classification of neuroendocrine neoplasms: lights and shadows.
Journal
Reviews in endocrine & metabolic disorders
Author(s)
La Rosa S., Uccella S.
ISSN
1573-2606 (Electronic)
ISSN-L
1389-9155
Publication state
Published
Issued date
09/2021
Peer-reviewed
Oui
Volume
22
Number
3
Pages
527-538
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations showing different morphological features, immunophenotype, molecular background, clinical presentation, and outcome. They can virtually originate in every organ of the human body and their classification is not uniform among different sites. Indeed, as they have historically been classified according to the organ in which they primarily arise, the different nomenclature that has resulted have created some confusion among pathologists and clinicians. Although a uniform terminology to classify neuroendocrine neoplasms arising in different systems has recently been proposed by WHO/IARC, some issues remain unsolved or need to be clarified. In this review, we discuss the lights and shadows of the current WHO classifications used to define and characterize NENs of the pituitary gland, lung, breast and those of the head and neck region, and digestive and urogenital systems.
Keywords
Humans, Neuroendocrine Tumors/diagnosis, Classification, Neuroendocrine carcinoma, Neuroendocrine neoplasm, Neuroendocrine tumor
Pubmed
Web of science
Open Access
Yes
Create date
11/11/2020 17:22
Last modification date
23/12/2021 7:34
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