Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_57A9835FCAA8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon.
Journal
Frontiers in immunology
Author(s)
Mylonas A., Conrad C.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
9
Pages
2746
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/T <sub>H</sub> 17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory diseases such as psoriasis. Although being highly effective in psoriasis treatment, anti-TNFs can themselves induce psoriasis-like skin lesions, a side effect called paradoxical psoriasis. In this review, we provide a comprehensive look at the different cellular and molecular players involved in classical plaque psoriasis and contrast its pathogenesis to paradoxical psoriasis, which is clinically similar but immunologically distinct. Classical psoriasis is a T-cell mediated autoimmune disease driven by TNF, characterised by T-cells memory, and a relapsing disease course. In contrast, paradoxical psoriasis is caused by the absence of TNF and represents an ongoing type-I interferon-driven innate inflammation that fails to elicit T-cell autoimmunity and lacks memory T cell-mediated relapses.
Keywords
Humans, Immunologic Memory, Interferon Type I/immunology, Interleukin-23/immunology, Psoriasis/immunology, Psoriasis/pathology, Signal Transduction/immunology, Th17 Cells/immunology, Th17 Cells/pathology, Tumor Necrosis Factor-alpha/immunology, IL-23, TH17, TNF, paradoxical psoriasis, plaque psoriasis, type I-interferon
Pubmed
Web of science
Open Access
Yes
Create date
17/12/2018 10:06
Last modification date
04/10/2019 6:08
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