Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassium.

Details

Serval ID
serval:BIB_578F0BAE6F69
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Chronic potassium depletion increases adrenal progesterone production that is necessary for efficient renal retention of potassium.
Journal
Kidney International
Author(s)
Elabida B., Edwards A., Salhi A., Azroyan A., Fodstad H., Meneton P., Doucet A., Bloch-Faure M., Crambert G.
ISSN
1523-1755 (Electronic)
ISSN-L
0085-2538
Publication state
Published
Issued date
2011
Volume
80
Number
3
Pages
256-262
Language
english
Abstract
Modern dietary habits are characterized by high-sodium and low-potassium intakes, each of which was correlated with a higher risk for hypertension. In this study, we examined whether long-term variations in the intake of sodium and potassium induce lasting changes in the plasma concentration of circulating steroids by developing a mathematical model of steroidogenesis in mice. One finding of this model was that mice increase their plasma progesterone levels specifically in response to potassium depletion. This prediction was confirmed by measurements in both male mice and men. Further investigation showed that progesterone regulates renal potassium handling both in males and females under potassium restriction, independent of its role in reproduction. The increase in progesterone production by male mice was time dependent and correlated with decreased urinary potassium content. The progesterone-dependent ability to efficiently retain potassium was because of an RU486 (a progesterone receptor antagonist)-sensitive stimulation of the colonic hydrogen, potassium-ATPase (known as the non-gastric or hydrogen, potassium-ATPase type 2) in the kidney. Thus, in males, a specific progesterone concentration profile induced by chronic potassium restriction regulates potassium balance.
Keywords
Adrenal Glands/drug effects, Adrenal Glands/enzymology, Aldosterone/biosynthesis, Analysis of Variance, Animals, Cell Line, Chronic Disease, Corticosterone/biosynthesis, Disease Models, Animal, Female, Gene Expression Regulation, Enzymologic, H(+)-K(+)-Exchanging ATPase/genetics, H(+)-K(+)-Exchanging ATPase/metabolism, Hormone Antagonists/pharmacology, Humans, Hypokalemia/enzymology, Hypokalemia/genetics, Kidney/drug effects, Kidney/enzymology, Male, Mice, Mice, Knockout, Mifepristone/pharmacology, Models, Biological, Potassium, Dietary/administration & dosage, Potassium, Dietary/metabolism, Progesterone/biosynthesis, Progesterone/blood, Receptors, Progesterone/antagonists & inhibitors, Receptors, Progesterone/metabolism, Sodium, Dietary/metabolism, Time Factors, Up-Regulation
Pubmed
Web of science
Open Access
Yes
Create date
04/10/2011 15:41
Last modification date
20/08/2019 15:11
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