Suppression of tumor angiogenesis by nonsteroidal anti-inflammatory drugs: a new function for old drugs.

Details

Serval ID
serval:BIB_578B685B5068
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Suppression of tumor angiogenesis by nonsteroidal anti-inflammatory drugs: a new function for old drugs.
Journal
TheScientificWorldJournal
Author(s)
Rüegg C., Dormond O.
ISSN
1537-744X
ISSN-L
1537-744X
Publication state
Published
Issued date
01/12/2001
Peer-reviewed
Oui
Volume
1
Pages
808-811
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
There is solid epidemiological evidence demonstrating that the regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing colorectal cancer, and to a lesser extent gastric and esophageal cancers[1]. Importantly, NSAIDs suppress colon polyp formation and progression in patients diagnosed with familial adenomatous polyposis coli (APC)[2]. In many animal studies, NSAIDs have been shown to prevent tumor formation and slow tumor progression, thus confirming and extending the clinical observations[3,4,5]. Recent findings have demonstrated that NSAIDs inhibit angiogenesis, suggesting that the tumor suppressive activity of these drugs may be due, at least in part, to their ability to inhibit tumor angiogenesis[6]. The study of the mechanism by which NSAIDs suppress tumor angiogenesis, is matter of intense research.
Keywords
Animals, Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, Antineoplastic Agents/therapeutic use, Humans, Neoplasms/blood supply, Neoplasms/drug therapy, Neovascularization, Pathologic/drug therapy
Pubmed
Open Access
Yes
Create date
28/01/2008 9:36
Last modification date
28/06/2024 11:19
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