Cardiac hypertrophy at autopsy.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_57776D20F214
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cardiac hypertrophy at autopsy.
Journal
Virchows Archiv
Author(s)
Basso C., Michaud K., d'Amati G., Banner J., Lucena J., Cunningham K., Leone O., Vink A., van der Wal A.C., Sheppard M.N.
Working group(s)
Association for European Cardiovascular Pathology
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Publication state
Published
Issued date
19/03/2021
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Since cardiac hypertrophy may be considered a cause of death at autopsy, its assessment requires a uniform approach. Common terminology and methodology to measure the heart weight, size, and thickness as well as a systematic use of cut off values for normality by age, gender, and body weight and height are needed. For these reasons, recommendations have been written on behalf of the Association for European Cardiovascular Pathology. The diagnostic work up implies the search for pressure and volume overload conditions, compensatory hypertrophy, storage and infiltrative disorders, and cardiomyopathies. Although some gross morphologic features can point to a specific diagnosis, systematic histologic analysis, followed by possible immunostaining and transmission electron microscopy, is essential for a final diagnosis. If the autopsy is carried out in a general or forensic pathology service without expertise in cardiovascular pathology, the entire heart (or pictures) together with mapped histologic slides should be sent for a second opinion to a pathologist with such an expertise. Indication for postmortem genetic testing should be integrated into the multidisciplinary management of sudden cardiac death.
Keywords
Autopsy, Cardiovascular diseases, Diagnostic criteria, Hypertrophy, Quality in pathology
Pubmed
Open Access
Yes
Create date
22/03/2021 9:38
Last modification date
26/03/2021 8:09
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