Differences in the miRNA signatures of chronic musculoskeletal pain patients from neuropathic or nociceptive origins.

Details

Serval ID
serval:BIB_57623B349BC7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Differences in the miRNA signatures of chronic musculoskeletal pain patients from neuropathic or nociceptive origins.
Journal
PloS one
Author(s)
Dayer C.F., Luthi F., Le Carré J., Vuistiner P., Terrier P., Benaim C., Giacobino J.P., Léger B.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
14
Number
7
Pages
e0219311
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The quality of life for millions of people worldwide is affected by chronic pain. In addition to the effect of chronic pain on well-being, chronic pain has also been associated with poor health conditions and increased mortality. Due to its multifactorial origin, the classification of pain types remains challenging. MicroRNAs (miRNA) are small molecules that regulate gene expression. They are released into the bloodstream in a stable manner under normal and pathological conditions and have been described as potential biomarkers. In the present study, we aimed to investigate whether pain may induce an aberrant, specific dysregulation of miRNA expression, depending on the origin of the pain.
To do so, we measured the expression changes of 184 circulating miRNAs (c-miRNAs) in the plasma samples of patients with different origins of chronic musculoskeletal pain. After statistical analyses, we identified seven c-miRNA candidates that were differentially expressed depending on the nociceptive or neuropathic origin of the pain. We then developed a two c-miRNA signature (hsa-miR-320a and hsa-miR-98-5p) that was able to correctly classify the pain type of 70% of the patients from the validation set.
In conclusion, circulating miRNAs are promising biomarkers to identify and characterize the chronic pain type and to further improve its clinical management.
Pubmed
Web of science
Open Access
Yes
Create date
21/07/2019 16:52
Last modification date
06/03/2020 7:20
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