A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions.

Details

Serval ID
serval:BIB_57554F3F7CF5
Type
Article: article from journal or magazin.
Publication sub-type
Minutes: analyse of a published work.
Collection
Publications
Institution
Title
A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions.
Journal
Gastroenterology
Author(s)
Dellon E.S., Khoury P., Muir A.B., Liacouras C.A., Safroneeva E., Atkins D., Collins M.H., Gonsalves N., Falk G.W., Spergel J.M., Hirano I., Chehade M., Schoepfer A.M., Menard-Katcher C., Katzka D.A., Bonis P.A., Bredenoord A.J., Geng B., Jensen E.T., Pesek R.D., Feuerstadt P., Gupta S.K., Lucendo A.J., Genta R.M., Hiremath G., McGowan E.C., Moawad F.J., Peterson K.A., Rothenberg M.E., Straumann A., Furuta G.T., Aceves S.S.
ISSN
1528-0012 (Electronic)
ISSN-L
0016-5085
Publication state
Published
Issued date
07/2022
Peer-reviewed
Oui
Volume
163
Number
1
Pages
59-76
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
Disease activity and severity of eosinophilic esophagitis (EoE) dictate therapeutic options and management, but the decision-making process for determining severity varies among practitioners. To reduce variability in practice patterns and help clinicians monitor the clinical course of the disease in an office setting, we aimed to create an international consensus severity scoring index for EoE.
A multidisciplinary international group of adult and pediatric EoE researchers and clinicians, as well as non-EoE allergy immunology and gastroenterology experts, formed 3 teams to review the existing literature on histology, endoscopy, and symptoms of EoE in the context of progression and severity. A steering committee convened a 1-day virtual meeting to reach consensus on each team's opinion on salient features of severity across key clinicopathologic domains and distill features that would allow providers to categorize disease severity.
Symptom features and complications and inflammatory and fibrostenotic features on both endoscopic and histologic examination were collated into a simplified scoring system-the Index of Severity for Eosinophilic Esophagitis (I-SEE)-that can be completed at routine clinic visits to assess disease severity using a point scale of 0-6 for mild, 7-14 for moderate, and ≥15 for severe EoE.
A multidisciplinary team of experts iteratively created a clinically usable EoE severity scoring system denominated "I-SEE" to guide practitioners in EoE management by standardizing disease components reflecting disease severity beyond eosinophil counts. I-SEE should be validated and refined using data from future clinical trials and routine clinical practice to increase its utilization and functionality.
Keywords
Adult, Child, Consensus, Endoscopy, Gastrointestinal, Enteritis, Eosinophilia, Eosinophilic Esophagitis/drug therapy, Eosinophilic Esophagitis/therapy, Gastritis, Humans, Severity of Illness Index, Complications, Endoscopy, Eosinophilic Esophagitis, Histology, Severity, Symptoms
Pubmed
Web of science
Open Access
Yes
Create date
31/05/2022 11:02
Last modification date
21/10/2023 7:08
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