Tipping the balance both ways: drug resistance and virulence in Candida glabrata.

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Ressource 1Download: serval:BIB_574D01DC8FBC.P001 (582.97 [Ko])
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Version: author
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Serval ID
serval:BIB_574D01DC8FBC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tipping the balance both ways: drug resistance and virulence in Candida glabrata.
Journal
FEMS Yeast Research
Author(s)
Vale-Silva L.A., Sanglard D.
ISSN
1567-1364 (Electronic)
ISSN-L
1567-1356
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
15
Number
4
Pages
fov025
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublishDocument Type: Review
Abstract
Among existing fungal pathogens, Candida glabrata is outstanding in its capacity to rapidly develop resistance to currently used antifungal agents. Resistance to the class of azoles, which are still widely used agents, varies in proportion (from 5 to 20%) depending on geographical area. Moreover, resistance to the class of echinocandins, which was introduced in the late 1990s, is rising in several institutions. The recent emergence of isolates with acquired resistance to both classes of agents is a major concern since alternative therapeutic options are scarce. Although considered less pathogenic than C. albicans, C. glabrata has still evolved specific virulence traits enabling its survival and propagation in colonized and infected hosts. Development of drug resistance is usually associated with fitness costs, and this notion is documented across several microbial species. Interestingly, azole resistance in C. glabrata has revealed the opposite. Experimental models of infection showed enhanced virulence of azole-resistant isolates. Moreover, azole resistance could be associated with specific changes in adherence properties to epithelial cells or innate immunity cells (macrophages), both of which contribute to virulence changes. Here we will summarize the current knowledge on C. glabrata drug resistance and also discuss the consequences of drug resistance acquisition on the balance between C. glabrata and its hosts.
Pubmed
Web of science
Open Access
Yes
Create date
08/08/2015 16:22
Last modification date
25/09/2019 7:09
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