Epidemiology of Candida species infections in critically ill non-immunosuppressed patients
Details
Serval ID
serval:BIB_572D9927D091
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Epidemiology of Candida species infections in critically ill non-immunosuppressed patients
Journal
Lancet Infectious Diseases
ISSN
1473-3099 (Print)
Publication state
Published
Issued date
11/2003
Volume
3
Number
11
Pages
685-702
Notes
Journal Article
Review --- Old month value: Nov
Review --- Old month value: Nov
Abstract
A substantial proportion of patients become colonised with Candida spp during hospital stay, but only few subsequently develop severe infection. Clinical signs of severe infection manifest early but lack specificity until late in the course of the disease, thus representing a particular challenge for diagnosis. Mostly nosocomial, invasive candidiasis occurs in only 1-8% of patients admitted to hospitals, but in around 10% of patients housed in intensive care units where it can represent up to 15% of all nosocomial infections. We review the epidemiology of invasive candidiasis in non-immunocompromised, critically ill patients with special emphasis on disease trends over time, pathophysiology, diagnostic approach, risk factors, and impact. Recent epidemiological data suggesting that the emergence of non-albicans candida strains with reduced susceptibility to azoles, previously linked to the use of new antifungals for empiric and prophylactic therapy in immunocompromised patients, may not have occurred in the critically ill. Management of invasive candidiasis in these patients will be addressed in the December issue of The Lancet Infectious Diseases.
Keywords
Antifungal Agents/*therapeutic use
Candida/*drug effects/isolation & purification
Candidiasis/drug therapy/*epidemiology/physiopathology
Cross Infection/drug therapy/*epidemiology/physiopathology
Humans
Incidence
Intensive Care Units
Microbial Sensitivity Tests
*Population Surveillance
Risk Factors
Species Specificity
World Health
Pubmed
Web of science
Create date
24/01/2008 17:57
Last modification date
20/08/2019 15:11