MRI Shows Lung Perfusion Changes after Vaping and Smoking.

Details

Serval ID
serval:BIB_56FE2D8984B1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
MRI Shows Lung Perfusion Changes after Vaping and Smoking.
Journal
Radiology
Author(s)
Nyilas S., Bauman G., Korten I., Pusterla O., Singer F., Ith M., Groen C., Schoeni A., Heverhagen J.T., Christe A., Rodondi N., Bieri O., Geiser T., Auer R., Funke-Chambour M., Ebner L.
ISSN
1527-1315 (Electronic)
ISSN-L
0033-8419
Publication state
Published
Issued date
07/2022
Peer-reviewed
Oui
Volume
304
Number
1
Pages
195-204
Language
english
Notes
Publication types: Journal Article ; Observational Study ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
Background Evidence regarding short-term effects of electronic nicotine delivery systems (ENDS) and tobacco smoke on lung ventilation and perfusion is limited. Purpose To examine the immediate effect of ENDS exposure and tobacco smoke on lung ventilation and perfusion by functional MRI and lung function tests. Materials and Methods This prospective observational pilot study was conducted from November 2019 to September 2021 (substudy of randomized controlled trial NCT03589989). Included were 44 healthy adult participants (10 control participants, nine former tobacco smokers, 13 ENDS users, and 12 active tobacco smokers; mean age, 41 years ± 12 [SD]; 28 men) who underwent noncontrast-enhanced matrix pencil MRI and lung function tests before and immediately after the exposure to ENDS products or tobacco smoke. Baseline measurements were acquired after 2 hours of substance abstinence. Postexposure measurements were performed immediately after the exposure. MRI showed semiquantitative measured impairment of lung perfusion (R <sub>Q</sub> ) and fractional ventilation (R <sub>FV</sub> ) impairment as percentages of affected lung volume. Lung clearance index (LCI) was assessed by nitrogen multiple-breath washout to capture ventilation inhomogeneity and spirometry to assess airflow limitation. Absolute differences were calculated with paired Wilcoxon signed-rank test and differences between groups with unpaired Mann-Whitney test. Healthy control participants underwent two consecutive MRI measurements to assess MRI reproducibility. Results MRI was performed and lung function measurement was acquired in tobacco smokers and ENDS users before and after exposure. MRI showed a decrease of perfusion after exposure (R <sub>Q</sub> , 8.6% [IQR, 7.2%-10.0%] to 9.1% [IQR, 7.8%-10.7%]; P = .03) and no systematic change in R <sub>FV</sub> (P = .31) among tobacco smokers. Perfusion increased in participants who used ENDS after exposure (R <sub>Q</sub> , 9.7% [IQR, 7.1%-10.9%] to 9.0% [IQR, 6.9%-10.0%]; P = .01). R <sub>FV</sub> did not change (P = .38). Only in tobacco smokers was LCI elevated after smoking (P = .02). Spirometry indexes did not change in any participants. Conclusion MRI showed a decrease of lung perfusion after exposure to tobacco smoke and an increase of lung perfusion after use of electronic nicotine delivery systems. © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Kligerman in this issue.
Keywords
Adult, Humans, Lung/diagnostic imaging, Magnetic Resonance Imaging/methods, Male, Perfusion, Prospective Studies, Reproducibility of Results, Smoking/adverse effects, Tobacco Smoke Pollution, Vaping/adverse effects
Pubmed
Web of science
Create date
11/04/2022 8:26
Last modification date
06/07/2022 6:35
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