Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series.

Details

Serval ID
serval:BIB_566475A4456B
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series.
Journal
Multiple sclerosis and related disorders
Author(s)
Bernard-Valnet R., Cobo-Calvo A., Siegfried A., Marasescu R., Bonnan M., Ballan G., Ellie E., Bauer J., Uro-Coste E., Marignier R., Brassat D.
ISSN
2211-0356 (Electronic)
ISSN-L
2211-0348
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
31
Pages
97-100
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory disease of the central nervous system, characterized by the presence of auto-antibodies directed against aquaporin-4 (AQP4) expressed on astrocyte end-feet. Despite NMOSD does not primarily belong to the spectrum of paraneoplastic neurological syndromes, rare cases of association with neoplasia have been outlined. Here, we report the association of NMOSD with ovarian teratoma in 3 cases. Pathological analysis of teratomas revealed glial component strongly expressing AQP4 and closely localized to immune infiltrates. Our series highlight the rare association of teratoma with NMOSD and the possible paraneoplastic mechanism.
Keywords
Adolescent, Adult, Aquaporin 4/metabolism, Female, Humans, Neuromyelitis Optica/complications, Neuromyelitis Optica/diagnosis, Neuromyelitis Optica/metabolism, Neuromyelitis Optica/pathology, Ovarian Neoplasms/complications, Ovarian Neoplasms/diagnosis, Ovarian Neoplasms/metabolism, Ovarian Neoplasms/pathology, Teratoma/complications, Teratoma/diagnosis, Teratoma/metabolism, Teratoma/pathology, Young Adult, Autoimmune diseases, Demyelinating diseases, Neuromyelitis optica, Ovarian teratoma, Paraneoplastic syndromes
Pubmed
Web of science
Create date
15/04/2019 18:35
Last modification date
04/01/2020 7:17
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