Diagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statement.

Details

Serval ID
serval:BIB_561A87B88814
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statement.
Journal
Journal of fungi
Author(s)
Jenks J.D., Gangneux J.P., Schwartz I.S., Alastruey-Izquierdo A., Lagrou K., Thompson Iii G.R., Lass-Flörl C., Hoenigl M.
Working group(s)
European Confederation of Medical Mycology (ECMM) Council Investigators
Contributor(s)
Adamski Z., Arikan-Akdagli S., Arsic-Arsenijevic V., Cornely O.A., Friberg N., Gow N., Hadina S., Hamal P., Juerna-Ellam M., Klimko N., Klingspor L., Lamoth F., Mares M., Matos T., Ozenci V., Papp T., Roilides E., Sabino R., Segal E., Talento A.F., Tortorano A.M., Verweij P.
ISSN
2309-608X (Electronic)
ISSN-L
2309-608X
Publication state
Published
Issued date
11/10/2020
Peer-reviewed
Oui
Volume
6
Number
4
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Breakthrough invasive fungal infections (bIFI) cause significant morbidity and mortality. Their diagnosis can be challenging due to reduced sensitivity to conventional culture techniques, serologic tests, and PCR-based assays in patients undergoing antifungal therapy, and their diagnosis can be delayed contributing to poor patient outcomes. In this review, we provide consensus recommendations on behalf of the European Confederation for Medical Mycology (ECMM) for the diagnosis of bIFI caused by invasive yeasts, molds, and endemic mycoses, to guide diagnostic efforts in patients receiving antifungals and support the design of future clinical trials in the field of clinical mycology. The cornerstone of lab-based diagnosis of breakthrough infections for yeast and endemic mycoses remain conventional culture, to accurately identify the causative pathogen and allow for antifungal susceptibility testing. The impact of non-culture-based methods are not well-studied for the definite diagnosis of breakthrough invasive yeast infections. Non-culture-based methods have an important role for the diagnosis of breakthrough invasive mold infections, in particular invasive aspergillosis, and a combination of testing involving conventional culture, antigen-based assays, and PCR-based assays should be considered. Multiple diagnostic modalities, including histopathology, culture, antibody, and/or antigen tests and occasionally PCR-based assays may be required to diagnose breakthrough endemic mycoses. A need exists for diagnostic tests that are effective, simple, cheap, and rapid to enable the diagnosis of bIFI in patients taking antifungals.
Keywords
breakthrough invasive fungal infections, diagnostics, endemic mycoses, invasive candidiasis, invasive mold infections
Pubmed
Web of science
Open Access
Yes
Create date
16/05/2022 17:02
Last modification date
17/05/2022 6:37
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