Brentuximab as a treatment for CD30+ mycosis fungoides and Sézary syndrome.

Details

Serval ID
serval:BIB_5614D00FB1E2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Brentuximab as a treatment for CD30+ mycosis fungoides and Sézary syndrome.
Journal
JAMA dermatology
Author(s)
Mehra T., Ikenberg K., Moos R.M., Benz R., Nair G., Schanz U., Haralambieva E., Hoetzenecker W., Dummer R., French L.E., Guenova E., Cozzio A.
ISSN
2168-6084 (Electronic)
ISSN-L
2168-6068
Publication state
Published
Issued date
01/2015
Peer-reviewed
Oui
Volume
151
Number
1
Pages
73-77
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The prognosis of advanced cutaneous T-cell lymphoma (CTCL), including Sézary syndrome and mycosis fungoides (MF), is poor. So far, no curative option apart from allogeneic stem cell transplantation is available. Large cell transformation often hallmarks cases with a more aggressive clinical course, and large tumor cells may express CD30. Recently, brentuximab vedotin, a conjugate of an anti-CD30 antibody and monomethylauristatin E, which inhibits the polymerization of microtubuli, has produced promising results in phase 2 trials in CD30+ Hodgkin lymphoma and anaplastic large cell lymphoma.
We describe 4 patients with advanced CTCL, 3 with MF and 1 with Sézary syndrome, who were treated with brentuximab. All patients had received multiple previous systemic therapies. In 2 cases of MF, a remission enabling subsequent allogeneic stem cell transplantation was achieved.
Brentuximab is a well-tolerated, promising new treatment option for advanced CTCL that can be integrated in an allogeneic stem cell transplantation plan by selectively depleting malignant CD30+ cutaneous lymphoma cells.
Keywords
Adult, Aged, Brentuximab Vedotin, Combined Modality Therapy, Female, Humans, Immunoconjugates/adverse effects, Immunoconjugates/therapeutic use, Ki-1 Antigen/immunology, Male, Middle Aged, Mycosis Fungoides/drug therapy, Mycosis Fungoides/pathology, Prognosis, Sezary Syndrome/drug therapy, Sezary Syndrome/pathology, Skin Neoplasms/drug therapy, Skin Neoplasms/pathology, Stem Cell Transplantation/methods, Transplantation, Homologous/methods
Pubmed
Web of science
Open Access
Yes
Create date
27/08/2020 14:59
Last modification date
02/09/2020 6:26
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