Metabolic View on Human Healthspan: A Lipidome-Wide Association Study.

Details

Serval ID
serval:BIB_55F845447D26
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic View on Human Healthspan: A Lipidome-Wide Association Study.
Journal
Metabolites
Author(s)
Carrard J., Gallart-Ayala H., Infanger D., Teav T., Wagner J., Knaier R., Colledge F., Streese L., Königstein K., Hinrichs T., Hanssen H., Ivanisevic J., Schmidt-Trucksäss A.
ISSN
2218-1989 (Print)
ISSN-L
2218-1989
Publication state
Published
Issued date
30/04/2021
Peer-reviewed
Oui
Volume
11
Number
5
Pages
287
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
As ageing is a major risk factor for the development of non-communicable diseases, extending healthspan has become a medical and societal necessity. Precise lipid phenotyping that captures metabolic individuality could support healthspan extension strategies. This study applied 'omic-scale lipid profiling to characterise sex-specific age-related differences in the serum lipidome composition of healthy humans. A subset of the COmPLETE-Health study, composed of 73 young (25.2 ± 2.6 years, 43% female) and 77 aged (73.5 ± 2.3 years, 48% female) clinically healthy individuals, was investigated, using an untargeted liquid chromatography high-resolution mass spectrometry approach. Compared to their younger counterparts, aged females and males exhibited significant higher levels in 138 and 107 lipid species representing 15 and 13 distinct subclasses, respectively. Percentage of difference ranged from 5.8% to 61.7% (females) and from 5.3% to 46.0% (males), with sphingolipid and glycerophophospholipid species displaying the greatest amplitudes. Remarkably, specific sphingolipid and glycerophospholipid species, previously described as cardiometabolically favourable, were found elevated in aged individuals. Furthermore, specific ether-glycerophospholipid and lyso-glycerophosphocholine species displayed higher levels in aged females only, revealing a more favourable lipidome evolution in females. Altogether, age determined the circulating lipidome composition, while lipid species analysis revealed additional findings that were not observed at the subclass level.
Keywords
Biochemistry, Molecular Biology, Endocrinology, Diabetes and Metabolism, healthspan, healthy population study, lipidomics, metabolic phenotyping, serum lipid signature
Pubmed
Web of science
Open Access
Yes
Create date
06/05/2021 15:37
Last modification date
05/06/2021 6:33
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