Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors.

Details

Serval ID
serval:BIB_55A7846A9C27
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors.
Journal
Cell
Author(s)
Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W.
ISSN
0092-8674[print], 0092-8674[linking]
Publication state
Published
Issued date
03/1992
Volume
68
Number
5
Pages
879-887
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Three novel members of the Xenopus nuclear hormone receptor superfamily have been cloned. They are related to each other and similar to the group of receptors that includes those for thyroid hormones, retinoids, and vitamin D3. Their transcriptional activity is regulated by agents causing peroxisome proliferation and carcinogenesis in rodent liver. All three Xenopus receptors activate the promoter of the acyl coenzyme A oxidase gene, which encodes the key enzyme of peroxisomal fatty acid beta-oxidation, via a cognate response element that has been identified. Therefore, peroxisome proliferators may exert their hypolipidemic effects through these receptors, which stimulate the peroxisomal degradation of fatty acids. Finally, the multiplicity of these receptors suggests the existence of hitherto unknown cellular signaling pathways for xenobiotics and putative endogenous ligands.
Keywords
Acyl-CoA Oxidase, Amino Acid Sequence, Animals, Base Sequence, Enzyme Induction, Fatty Acids/metabolism, Gene Expression Regulation/genetics, Microbodies/metabolism, Molecular Sequence Data, Oxidation-Reduction, Oxidoreductases/biosynthesis, Oxidoreductases/genetics, RNA, Messenger/analysis, Receptors, Cell Surface/biosynthesis, Receptors, Cell Surface/drug effects, Receptors, Cytoplasmic and Nuclear, Sequence Alignment, Transcription Factors/biosynthesis, Transcription Factors/genetics, Xenopus laevis/genetics
Pubmed
Web of science
Create date
24/01/2008 16:04
Last modification date
20/08/2019 14:10
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