Histological scoring of chronic hepatitis.

Details

Serval ID
serval:BIB_559B16C43BA4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Histological scoring of chronic hepatitis.
Journal
Acta Gastro-enterologica Belgica
Author(s)
Sempoux C., Rahier J.
ISSN
1784-3227 (Print)
ISSN-L
1784-3227
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
67
Number
3
Pages
290-293
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Liver biopsy is considered to be the most specific analysis to assess the nature and severity of liver disease. In case of chronic hepatitis, scoring liver biopsies is an established part of the pathologist's work. Four different scores are most often used: the Scheuer, Ludwig and French METAVIR systems, which are fairly simple, and the Ischak score, which is more complex. All systems generate scores, which are based upon inflammatory activity (the grade) and fibrosis (the stage), with splitting of these two components. To be valid in routine analyses, a scoring system must be clinically relevant, reproducible and simple to understand and to apply. Scoring will then be helpful to study series of patients and to evaluate the efficacy of new therapeutic strategies. However, a score does not replace the study of a liver biopsy and the generated numbers does not correspond to true measurements. Furthermore, its accuracy will always depend on adequate sampling.
Keywords
Algorithms, Biopsy, Hepatitis, Chronic/pathology, Humans, Liver/pathology, Severity of Illness Index
Pubmed
Web of science
Create date
20/10/2016 16:22
Last modification date
20/08/2019 14:10
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