Influence of host cell type and V3 loop of the surface glycoprotein on susceptibility of human immunodeficiency virus type 1 to polyanion compounds

Details

Serval ID
serval:BIB_5594DEB3AA71
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of host cell type and V3 loop of the surface glycoprotein on susceptibility of human immunodeficiency virus type 1 to polyanion compounds
Journal
Antimicrobial Agents and Chemotherapy
Author(s)
Meylan  P. R., Kornbluth  R. S., Zbinden  I., Richman  D. D.
ISSN
0066-4804 (Print)
Publication state
Published
Issued date
12/1994
Volume
38
Number
12
Pages
2910-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
Dextran sulfate is a potent inhibitor of human immunodeficiency virus (HIV) binding and replication in lymphocytic cell lines. In this study, we demonstrate that the effect of dextran sulfate and heparin depends on the host cell type and on the V3 loop, the principal neutralizing determinant of HIV gp120. In particular, when dextran sulfate was tested on primary human macrophages infected with macrophage-tropic viruses, enhancement of infection was observed in 6 of 11 independent macrophage preparations and with 5 of 13 primary HIV isolates. Our in vitro observations might explain why enhanced HIV replication was observed in HIV-infected patients treated with dextran sulfate.
Keywords
Cell Line Dextran Sulfate/*pharmacology HIV Envelope Protein gp120/*physiology HIV-1/*drug effects Heparin/*pharmacology Humans Virus Replication/drug effects
Pubmed
Web of science
Create date
25/01/2008 14:32
Last modification date
20/08/2019 14:10
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