Effect of a high fructose diet on metabolic parameters in carriers for hereditary fructose intolerance.

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State: Public
Version: author
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_5592E5FCEA72
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of a high fructose diet on metabolic parameters in carriers for hereditary fructose intolerance.
Journal
Clinical nutrition
Author(s)
Debray F.G., Seyssel K., Fadeur M., Tappy L., Paquot N., Tran C.
ISSN
1532-1983 (Electronic)
ISSN-L
0261-5614
Publication state
Published
Issued date
06/2021
Peer-reviewed
Oui
Volume
40
Number
6
Pages
4246-4254
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Hyperuricemia is an independent risk factor for the metabolic syndrome and cardiovascular disease. We hypothesized that asymptomatic carriers for hereditary fructose intolerance (OMIM 22960) would have increased uric acid and altered component of the metabolic syndrome when exposed to fructose overfeeding.
Six heterozygotes for HFI (hHFI) and 6 controls (Ctrl) were studied in a randomized, controlled, crossover trial. Participants ingested two identical test meals containing 0.7 g kg <sup>-1</sup> glucose and 0.7 g kg <sup>-1</sup> fructose according to a cross-over design, once after a 7-day on a low fructose diet (LoFruD, <10 g/d) and on another occasion after 7 days on a high fructose diet (HiFruD, 1.4 g kg <sup>-1</sup> day <sup>-1</sup> fructose + 0.1 g kg <sup>-1</sup> day <sup>-1</sup> glucose). Uric acid, glucose, and insulin concentrations were monitored in fasting conditions and over 2 h postprandial, and insulin resistance indexes were calculated.
HiFruD increased fasting uric acid (p < 0.05) and reduced fasting insulin sensitivity estimated by the homeostasis model assessment (HOMA) for insulin resistance (p < 0.05), in both groups. Postprandial glucose concentrations were not different between hHFI and Ctrl. However HiFruD increased postprandial plasma uric acid, insulin and hepatic insulin resistance index (HIRI) in hHFI only (all p < 0.05).
Seven days of HiFruD increased fasting uric acid and slightly reduced fasting HOMA index in both groups. In contrast, HiFruD increased postprandial uric acid, insulin concentration and HIRI in hHFI only, suggesting that heterozygosity for pathogenic Aldolase B variants may confer an increased susceptibility to the effects of dietary fructose on uric acid and hepatic insulin sensitivity. This trial was registered at the U.S. Clinical Trials Registry as NCT03545581.
Keywords
Fructose, Healthy carriers, Hereditary fructose intolerance, Insulin, Uric acid
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2021 15:33
Last modification date
24/07/2021 6:34
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