Substrate metabolism, nutrient balance and obesity development in children and adolescents: a target for intervention?

Details

Serval ID
serval:BIB_5591FE752F8F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Substrate metabolism, nutrient balance and obesity development in children and adolescents: a target for intervention?
Journal
Obesity Reviews
Author(s)
Sun M., Schutz Y., Maffeis C.
ISSN
1467-7881 (Print)
ISSN-L
1467-7881
Publication state
Published
Issued date
11/2004
Volume
5
Number
4
Pages
183-188
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Obesity results from the organism's inability to maintain energy balance over a long term. Childhood obesity and its related factors and pathological consequences tend to persist into adulthood. A cluster of factors, including high energy density in the diet (high fat intake), low energy expenditure, and disturbed substrate oxidation, favour the increase in fat mass. Oxidation of three major macronutrients and their roles in the regulation of energy balance, particularly in children and adolescents, are discussed. Total glucose oxidation is not different between obese and lean children; exogenous glucose utilization is higher whereas endogenous glucose utilization is lower in obese compared with lean children. Carbohydrate composition of the diet determines carbohydrate oxidation regardless of fat content of the diet. Both exogenous and endogenous fat oxidation are higher in obese than in lean subjects. The influence of high fat intake on accumulation of fat mass is operative rather over a long term. Several future directions are addressed, such that a combination of increased physical activity and modification in diet composition, in terms of energy density and glycemic index, is recommended for children and adolescents.
Keywords
Adolescent, Adolescent Nutritional Physiological Phenomena, Blood Glucose/metabolism, Body Composition/physiology, Child, Child Nutrition Disorders/metabolism, Child Nutrition Disorders/prevention & control, Child Nutritional Physiological Phenomena, Dietary Carbohydrates/administration & dosage, Dietary Carbohydrates/metabolism, Dietary Fats/administration & dosage, Dietary Fats/metabolism, Energy Metabolism/physiology, Glycemic Index, Humans, Obesity/metabolism, Obesity/prevention & control
Pubmed
Create date
21/01/2008 13:09
Last modification date
20/08/2019 14:10
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