At the bench: Pre‐clinical evidence for multiple functions of CXCR4 in cancer

Details

Serval ID
serval:BIB_55863C1885F3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
At the bench: Pre‐clinical evidence for multiple functions of CXCR4 in cancer
Journal
Journal of Leukocyte Biology
Author(s)
Luker Gary D, Yang Jinming, Richmond Ann, Scala Stefania, Festuccia Claudio, Schottelius Margret, Wester Hans-Jürgen, Zimmermann Johann
ISSN
0741-5400
1938-3673
ISSN-L
0741-5400
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Signaling through chemokine receptor, C-X-C chemokine receptor type 4 (CXCR4) regulates essential processes in normal physiology, including embryogenesis, tissue repair, angiogenesis, and trafficking of immune cells. Tumors co-opt many of these fundamental processes to directly stimulate proliferation, invasion, and metastasis of cancer cells. CXCR4 signaling contributes to critical functions of stromal cells in cancer, including angiogenesis and multiple cell types in the tumor immune environment. Studies in animal models of several different types of cancers consistently demonstrate essential functions of CXCR4 in tumor initiation, local invasion, and metastasis to lymph nodes and distant organs. Data from animal models support clinical observations showing that integrated effects of CXCR4 on cancer and stromal cells correlate with metastasis and overall poor prognosis in >20 different human malignancies. Small molecules, Abs, and peptidic agents have shown anticancer efficacy in animal models, sparking ongoing efforts at clinical translation for cancer therapy. Investigators also are developing companion CXCR4-targeted imaging agents with potential to stratify patients for CXCR4-targeted therapy and monitor treatment efficacy. Here, pre-clinical studies demonstrating functions of CXCR4 in cancer are reviewed.
Keywords
Immunology, Cell Biology
Pubmed
Web of science
Create date
02/11/2020 12:52
Last modification date
19/11/2020 6:26
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