Progrès récents et orientations futures de la thérapie avec cellules CAR-T en oncologie pédiatrique [Recent advances and future directions in CAR-T cell therapy in pediatric oncology]

Details

Serval ID
serval:BIB_556228939270
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Progrès récents et orientations futures de la thérapie avec cellules CAR-T en oncologie pédiatrique [Recent advances and future directions in CAR-T cell therapy in pediatric oncology]
Journal
Revue medicale suisse
Author(s)
Ceppi F., Renella R., Diezi M., Ansari M., Duchosal M.A., Arber C., Kandalaft L., Coukos G., Beck-Popovic M.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
09/01/2019
Peer-reviewed
Oui
Volume
15
Number
N° 632-633
Pages
85-91
Language
french
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Fighting leukemia using the immune system (antibodies, lymphocytes) is an old idea, which has already been fulfilled in allogeneic bone marrow transplantation. Indeed, the effectiveness of the transplant depends on the action of the donor lymphocytes. To limit the adverse effects on bystander organs (graft-versus-host disease), autologous T cells can be engineered to express synthetic chimeric antigen receptors (CARs) with artificially redirected antigen specificity. Autologous T cells engineered to express a CAR targeting CD19 have shown unprecedented efficacy in clinical trials for relapsed/refractory B-cell leukemias and lymphomas. In this review article, we describe the therapeutic strategies, clinical trial results, side effects and future direction of CAR T cell therapy in B cell acute lymphoblastic leukemia and other pediatric cancers and its future role in the Swiss setting.
Keywords
Antigens, CD19, Cell- and Tissue-Based Therapy, Child, Humans, Immunotherapy, Adoptive, Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Receptors, Antigen, T-Cell, T-Lymphocytes
Pubmed
Create date
15/01/2019 11:38
Last modification date
01/11/2019 9:44
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