Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span.

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State: Public
Version: Final published version
Serval ID
serval:BIB_554047C3A262
Type
Article: article from journal or magazin.
Collection
Publications
Title
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span.
Journal
NPJ Aging and Mechanisms of Disease
Author(s)
Garschall K., Dellago H., Gáliková M., Schosserer M., Flatt T., Grillari J.
ISSN
2056-3973 (Print)
ISSN-L
2056-3973
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
3
Pages
5
Language
english
Abstract
Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to detect and respond to DNA damage, various insults from environmental and endogenous sources continuously affect DNA integrity. Over time this can lead to the accumulation of somatic mutations, which is thought to be one of the major causes of aging. We have previously found that overexpression of the essential human DNA repair and splicing factor SNEV, also called PRP19 or hPso4, extends replicative life span of cultured human endothelial cells and impedes accumulation of DNA damage. Here, we show that adult-specific overexpression of dPrp19, the D. melanogaster ortholog of human SNEV/PRP19/hPso4, robustly extends life span in female fruit flies. This increase in life span is accompanied by reduced levels of DNA damage and improved resistance to oxidative and genotoxic stress. Our findings suggest that dPrp19 plays an evolutionarily conserved role in aging, life span modulation and stress resistance, and support the notion that superior DNA maintenance is key to longevity.

Pubmed
Web of science
Open Access
Yes
Create date
06/07/2017 17:52
Last modification date
20/08/2019 15:09
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