Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study

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Serval ID
serval:BIB_552C347CF4FA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study
Journal
British Journal of Cancer
Author(s)
Franceschi  S., Polesel  J., Rickenbach  M., Dal Maso  L., Probst-Hensch  N. M., Fux  C., Cavassini  M., Hasse  B., Kofler  A., Ledergerber  B., Erb  P., Clifford  G. M.
ISSN
0007-0920 (Print)
Publication state
Published
Issued date
12/2006
Volume
95
Number
11
Pages
1598-602
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 4
Abstract
Infections with hepatitis C virus (HCV) and, possibly, hepatitis B virus (HBV) are associated with an increased risk of non-Hodgkin's lymphoma (NHL) in the general population, but little information is available on the relationship between hepatitis viruses and NHL among people with HIV (PHIV). We conducted a matched case-control study nested in the Swiss HIV Cohort Study (SHCS). Two hundred and ninety-eight NHL cases and 889 control subjects were matched by SHCS centre, gender, age group, CD4+ count at enrollment, and length of follow-up. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using logistic regression to evaluate the association between NHL and seropositivity for antibodies against HCV (anti-HCV) and hepatitis B core antigen (anti-HBc), and for hepatitis B surface antigen (HBsAg). Anti-HCV was not associated with increased NHL risk overall (OR = 1.05; 95% CI: 0.63-1.75), or in different strata of CD4+ count, age or gender. Only among men having sex with men was an association with anti-HCV found (OR = 2.37; 95% CI: 1.03-5.43). No relationships between NHL risk and anti-HBc or HBsAg emerged. Coinfection with HIV and HCV or HBV did not increase NHL risk compared to HIV alone in the SHCS.
Keywords
Adult Case-Control Studies Cohort Studies Female HIV Infections/*complications Hepacivirus Hepatitis B/complications Hepatitis B virus Hepatitis C/*complications Homosexuality, Male Humans Lymphoma, Non-Hodgkin/complications/*epidemiology/virology Male Middle Aged Risk Factors Switzerland
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 8:52
Last modification date
20/08/2019 14:09
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