Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts
Details
Serval ID
serval:BIB_54EA4B6EFDD3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts
Journal
Neuropeptides
ISSN
0143-4179 (Print)
Publication state
Published
Issued date
08/2004
Volume
38
Number
4
Pages
267-75
Notes
Journal Article
Review --- Old month value: Aug
Review --- Old month value: Aug
Abstract
The peptidic neurotransmitter neuropeptide Y (NPY) has been functionally implicated in feeding behavior, cardiovascular regulation, control of neuroendocrine axes, affective disorders, seizures, and memory retention. At least five different receptors mediate NPY actions. In particular, the Y1 receptor appears to be involved in a variety of NPY-induced pathways. This review summarizes the main findings resulting from the use of mice lacking NPY Y1 receptor expression. Interestingly, the overall phenotype of Y1 knockouts mimics metabolic syndrome, which is characterized by obesity, a prediabetic state, and a susceptibility to develop hypertension.
Keywords
Animals
Blood Pressure/physiology
Energy Metabolism
Homeostasis
Hypothalamo-Hypophyseal System/physiology
Mice
*Mice, Knockout
Obesity/metabolism
Receptors, Neuropeptide Y/genetics/*metabolism
Signal Transduction/*physiology
Pubmed
Web of science
Create date
25/01/2008 8:45
Last modification date
20/08/2019 14:09