Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer.

Details

Serval ID
serval:BIB_54C39E31A537
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer.
Journal
EJNMMI research
Author(s)
Wang H., Remke M., Horn T., Schwamborn K., Chen Y., Steiger K., Weichert W., Wester H.J., Schottelius M., Weber W.A., Eiber M.
ISSN
2191-219X (Print)
ISSN-L
2191-219X
Publication state
Published
Issued date
16/11/2023
Peer-reviewed
Oui
Volume
13
Number
1
Pages
99
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Targeting prostate-specific membrane antigen (PSMA) has been highly successful for imaging and treatment of prostate cancer. However, heterogeneity in immunohistochemistry indicates limitations in the effect of imaging and radionuclide therapy of multifocal disease. <sup>99m</sup> Tc-PSMA-I&S is a γ-emitting probe, which can be used for intraoperative lesion detection and postsurgical autoradiography (ARG). We aimed to study its intraprostatic distribution and compared it with (immuno)-histopathology.
Seventeen patients who underwent RGS between 11/2018 and 01/2020 with a total of 4660 grids were included in the preliminary analysis. Marked intratumor and intra-patient heterogeneity of PSMA expression was detected, and PSMA negative foci were observed in all samples (100%). Heterogeneous intra-patient PSMA-ligand uptake was observed, and no significant correlation was present between the degree of heterogeneity of PSMA expression and PSMA-ligand uptake. Higher PSMA-ligand uptake was observed in GS ≥ 8 than GS < 8 (p < 0.001). The appearance of Gleason Pattern (GP) 4 was strongly associated with higher uptake (coefficient: 0.43, p < 0.001), while GP 5 also affected the uptake (coefficient: 0.07, p < 0.001).
PSMA expression and PSMA-ligand uptake show marked heterogeneity. Prostate carcinoma with GP 4 showed significantly higher uptake compared with non-neoplastic prostate tissue. Our analyses extend the scope of applications of radiolabeled PSMA-ligands to ARG for identifying high-grade disease and using its signal as a noninvasive biomarker in prostate cancer.
Keywords
99mTc-PSMA-I&S, Arg, Heterogeneity, Immunohistochemistry, Primary prostate cancer, ARG
Pubmed
Web of science
Open Access
Yes
Create date
23/11/2023 14:56
Last modification date
20/12/2023 7:16
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