Deciphering the landscape of phosphorylated HLA-II ligands.

Details

Serval ID
serval:BIB_54BD67DD87D2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Deciphering the landscape of phosphorylated HLA-II ligands.
Journal
iScience
Author(s)
Solleder M., Racle J., Guillaume P., Coukos G., Bassani-Sternberg M., Gfeller D.
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Publication state
Published
Issued date
20/05/2022
Peer-reviewed
Oui
Volume
25
Number
5
Pages
104215
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
CD4 <sup>+</sup> T cell activation in infectious diseases and cancer is governed by the recognition of peptides presented on class II human leukocyte antigen (HLA-II) molecules. Therefore, HLA-II ligands represent promising targets for vaccine design and personalized cancer immunotherapy. Much work has been done to identify and predict unmodified peptides presented on HLA-II molecules. However, little is known about the presentation of phosphorylated HLA-II ligands. Here, we analyzed Mass Spectrometry HLA-II peptidomics data and identified 1,943 unique phosphorylated HLA-II ligands. This enabled us to precisely define phosphorylated binding motifs for more than 30 common HLA-II alleles and to explore various molecular properties of phosphorylated peptides. Our data were further used to develop the first predictor of phosphorylated peptide presentation on HLA-II molecules.
Keywords
Cell biology, Immunology, Omics
Pubmed
Web of science
Open Access
Yes
Create date
26/05/2022 10:14
Last modification date
15/07/2022 6:36
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