Réactions d’hypersensibilité au fer intraveineux : le point de vue de l’allergologue [Hypersensitivity reactions to intravenous iron: an allergist' perspective]

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UNIL restricted access
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_549B88D4BEB5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Réactions d’hypersensibilité au fer intraveineux : le point de vue de l’allergologue [Hypersensitivity reactions to intravenous iron: an allergist' perspective]
Journal
Revue medicale suisse
Author(s)
Moi L., Stehlin F., Desseauve D., Ribi C., Muller Y.D.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
06/04/2022
Peer-reviewed
Oui
Volume
18
Number
776
Pages
639-645
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Intravenous iron infusions rarely result in severe hypersensitivity reactions. The primary suspected hypersensitivity mechanism is an abnormal complement activation by non-IgE antibodies to the carbohydrate moieties stabilizing iron formulations. A major risk factor for hypersensitivity reactions is related to the infusion speed. Fishbane-like reactions usually resolve after pausing the infusion, which can be resumed under medical surveillance and at a lower infusion rate. Yet, anaphylactic reactions require emergency first aid and subsequent strict avoidance of intravenous iron. Desensitization protocols can be implemented in selected cases and under strict medical surveillance to reduce the risks of severe reactions upon re-exposure.
Keywords
Administration, Intravenous, Allergists, Anaphylaxis/chemically induced, Anemia, Iron-Deficiency/drug therapy, Drug Hypersensitivity/diagnosis, Drug Hypersensitivity/etiology, Drug Hypersensitivity/therapy, Humans, Infusions, Intravenous, Iron/adverse effects
Pubmed
Create date
25/04/2022 12:28
Last modification date
21/11/2022 8:29
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