General mechanisms of coagulation and targets of anticoagulants (Section I). Position Paper of the ESC Working Group on Thrombosis - Task Force on Anticoagulants in Heart Disease.

Details

Serval ID
serval:BIB_549AA3A3396E
Type
Article: article from journal or magazin.
Collection
Publications
Title
General mechanisms of coagulation and targets of anticoagulants (Section I). Position Paper of the ESC Working Group on Thrombosis - Task Force on Anticoagulants in Heart Disease.
Journal
Thrombosis and Haemostasis
Author(s)
De Caterina R., Husted S., Wallentin L., Andreotti F., Arnesen H., Bachmann F., Baigent C., Huber K., Jespersen J., Kristensen S.D., Lip G.Y., Morais J., Rasmussen L.H., Siegbahn A., Verheugt F.W., Weitz J.I.
ISSN
0340-6245 (Print)
ISSN-L
0340-6245
Publication state
Published
Issued date
2013
Volume
109
Number
4
Pages
569-579
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Contrary to previous models based on plasma, coagulation processes are currently believed to be mostly cell surface-based, including three overlapping phases: initiation, when tissue factor-expressing cells and microparticles are exposed to plasma; amplification, whereby small amounts of thrombin induce platelet activation and aggregation, and promote activation of factors (F)V, FVIII and FXI on platelet surfaces; and propagation, in which the Xase (tenase) and prothrombinase complexes are formed, producing a burst of thrombin and the cleavage of fibrinogen to fibrin. Thrombin exerts a number of additional biological actions, including platelet activation, amplification and self-inhibition of coagulation, clot stabilisation and anti-fibrinolysis, in processes occurring in the proximity of vessel injury, tightly regulated by a series of inhibitory mechanisms. "Classical" anticoagulants, including heparin and vitamin K antagonists, typically target multiple coagulation steps. A number of new anticoagulants, already developed or under development, target specific steps in the process, inhibiting a single coagulation factor or mimicking natural coagulation inhibitors.
Pubmed
Web of science
Create date
16/05/2013 17:57
Last modification date
20/08/2019 15:09
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