Lymph node involvement by enteropathy-like indolent NK-cell proliferation.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_54935FA3A9BF
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Lymph node involvement by enteropathy-like indolent NK-cell proliferation.
Journal
Virchows Archiv
Author(s)
Dargent J.L., Tinton N., Trimech M., de Leval L.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Publication state
Published
Issued date
06/2021
Peer-reviewed
Oui
Volume
478
Number
6
Pages
1197-1202
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein-Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes.
Keywords
Gallbladder, Gastrointestinal, Indolent NK-cell lymphoproliferative disorder, Lymph node, Lymphomatoid gastropathy, NK-cell enteropathy
Pubmed
Web of science
Open Access
Yes
Create date
24/07/2020 13:44
Last modification date
22/06/2021 6:37
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